Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The discovery of immunoglobulin E.

S G O Johansson1

  • 1Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institute, Stockholm, Sweden. s.g.o.johansson@ki.se

Allergy and Asthma Proceedings
|May 26, 2006
PubMed
Summary

Scientists discovered immunoglobulin E (IgE) in 1968, a key factor in allergic reactions. Understanding IgE has since advanced allergy diagnosis and treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Individually dosed omalizumab facilitates peanut oral immunotherapy in peanut allergic adolescents.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2019
Same author

Individually dosed omalizumab: an effective treatment for severe peanut allergy.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2016
Same author

Six years without pholcodine; Norwegians are significantly less IgE-sensitized and clinically more tolerant to neuromuscular blocking agents.

Allergy·2016
Same author

The discovery of IgE.

The Journal of allergy and clinical immunology·2016
Same author

Evaluation of basophil allergen threshold sensitivity (CD-sens) to peanut and Ara h 8 in children IgE-sensitized to Ara h 8.

Clinical and molecular allergy : CMA·2015
Same author

IgG4 antibodies and peanut challenge outcome in children IgE-sensitized to peanut.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2015

Area of Science:

  • Immunology
  • Allergy Research

Background:

  • Early observations in 1919 suggested a serum factor caused transfusion-related asthma.
  • A prolonged search was necessary to identify the specific allergy-mediating factor.

Purpose of the Study:

  • To highlight the historical identification and significance of immunoglobulin E (IgE).
  • To underscore the impact of IgE knowledge on allergy research and clinical practice.

Main Methods:

  • Historical review of allergy research.
  • Recognition of immunoglobulin E (IgE) by the World Health Organization in 1968.

Main Results:

  • Identification of immunoglobulin E (IgE) as the primary antibody mediating allergic reactions.
  • Significant advancements in understanding allergic inflammation.

Conclusions:

  • The discovery of IgE revolutionized allergy diagnosis and treatment strategies.
  • Continued research into IgE pathways offers further therapeutic potential for allergic diseases.

Related Experiment Videos