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Updated: Aug 8, 2026
2D-HPLC-MS Technology Combined with Molecular Network for the Identification of Components in Tibetan Medicine Aconitum pendulum
Published on: December 8, 2023
[Non-alkaloid constituents from a Tibetan medicine Meconopsis quintuplinervia]
Xiao-Ya Shang1, Chong Li, Cheng-Zhong Zhang
1Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Be'iing 100050, China.
Objective:
To study the chemical constituents of a Tibetan medicine Meconopsis quintuplinervia.
Method:
Column chromatographic techniques were applied to isolate constituents. A combination of IR, MS and NMR spectroscopy was used to identify structures of constituents.
Result:
Twelve compounds were isolated from the ethanolic extract and their structures were elucidated as quercetin 3-O-beta-D-glucopyranoside (I), quercetin 3-O-beta-D-galactopyranosyl-(1-->6)-glucopyranoside (II), kaempferol 3-O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranoside (III), isorhamnetin 3-0-beta-D-galactopyranosyl-(1-->6)-beta-D-glucopyranoside (IV), caffeic acid (V), protocatechuic acid (VI), p-hydroxycinnamic (VII), 2-(3,4-dihydroxyphenyl )-ethyl-O-beta-D-glucopyranoside (VIII), p-hydroxybenzoyl-beta-D-glucopyranoside (IX), 4-O-beta-D-glucopyranosyl-(Z)-p-coumaric acid (X), 5, 7-dihydroxy-4H-4-chromenone (XI), daucosterol (XII).
Conclusion:
Ten compounds were isolated from this genus for the first time except for XI and XII.
