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[Clinical proteomics in laboratory medicine]
1Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba 260-8670.
Rinsho Byori. the Japanese Journal of Clinical Pathology
|May 26, 2006
Summary
Proteomics advances enable novel biomarker discovery for heavy alcohol consumption and esophageal cancer. SELDI-TOF MS identified a peptide marker for alcohol use, while 2-DE identified downregulated periplakin in esophageal cancer.
Area of Science:
- Proteomics: The study of protein expression and function.
- Biomarker Discovery: Identifying molecular indicators for disease diagnosis and monitoring.
Context:
- The shift from genomics to proteomics highlights the importance of protein-level analysis.
- Clinical proteomics utilizes advanced methodologies like SELDI-TOF MS and 2-DE for disease research.
Purpose:
- To identify novel protein biomarkers for heavy alcohol consumption and esophageal cancer.
- To leverage advanced proteomic techniques for clinical applications.
Summary:
- Surface-enhanced laser/desorption ionization time-of-flight mass spectrometry (SELDI-TOF MS) identified a 5.9kD peptide as a potential marker for heavy alcohol consumption.
- Two-dimensional electrophoresis (2-DE) and 2-D DIGE identified periplakin, a 195-kDa protein, significantly downregulated in esophageal cancer tissues.
Impact:
- These findings contribute to the development of objective markers for alcohol consumption and early cancer detection.
- Clinical proteomics is poised to significantly impact laboratory medicine and patient care.
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