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Updated: Aug 8, 2026

Preparing a 68Ga-labeled Arginine Glycine Aspartate (RGD)-peptide for Angiogenesis
Published on: January 7, 2019
Novel and selective alpha(v)beta3 receptor peptide antagonist: design, synthesis, and biological behavior
Annarita Del Gatto1, Laura Zaccaro, Paolo Grieco
1Institute of Biostructures and Bioimaging, CNR, Department of Biological Sciences, University of Naples Federico II, and C. I. R. Pe. B., via Mezzocannone 16, 80134 Naples, Italy.
Abstract:
Among RGD-dependent integrins, the alpha(v)beta3 receptor has recently received increasing attention as a therapeutic target because of its critical role in tumor-induced angiogenesis and metastasis formation. Here, we describe a new peptide antagonist of alpha(v)beta3 receptor, designed on the basis of the crystal structure of integrin alpha(v)beta3 in complex with c(RGDf[NMe]V) and the NMR structure of echistatin. Cell adhesion assays have demonstrated that the peptide is a potent and selective antagonist of the alpha(v)beta3 receptor.
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