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The efficacy of cefdinir in acute bacterial rhinosinusitis

James A Hadley1

  • 1University of Rochester Medical Center, Rochester, NY, USA. hadley@urmc.rochester.edu

Expert Opinion on Pharmacotherapy
|May 26, 2006
PubMed

Insights

Cefdinir is an effective once-daily oral antibiotic for acute bacterial rhinosinusitis, showing comparable efficacy to other treatments with good tolerability and convenient dosing.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Otolaryngology

Background:

  • Acute bacterial rhinosinusitis (ABRS) is a prevalent infection causing significant illness.
  • Common pathogens include Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.

Purpose of the Study:

  • To evaluate cefdinir as a treatment option for ABRS.
  • To assess its efficacy, tolerability, and convenience compared to other regimens.

Main Methods:

  • Randomized clinical trials comparing cefdinir to amoxicillin/clavulanate and levofloxacin.
  • Evaluation of clinical efficacy, safety, and patient-reported outcomes.

Main Results:

  • Cefdinir demonstrated efficacy similar to comparator treatments.
  • It is well-tolerated with minimal impact on normal flora.
  • Cefdinir oral suspension is palatable for pediatric patients.

Conclusions:

  • Cefdinir is a convenient and effective first-line treatment for mild ABRS, especially when once-daily dosing is desired.
  • It offers a favorable option due to its efficacy, tolerability, and dosing schedule.

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