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Published on: December 5, 2025
Opportunities and risks of using heliox in your clinical practice
1Nektar Therapeutics, 2071 Stierlin Court, Mountain View, CA 94043, USA. jfink@ca.nektar.com
Helium-oxygen (heliox) administration has evolved, with devices now available to reduce risks associated with its clinical use. This review covers heliox delivery devices and their safe application.
Area of Science:
- Medical Devices
- Respiratory Therapy
- Gas Mixtures
Background:
- Helium-oxygen mixture (heliox) has been used clinically since 1934.
- Clinical applications for heliox have expanded significantly.
- Historically, heliox administration required modifications of non-heliox specific devices.
Purpose of the Study:
- To review devices essential for heliox administration.
- To examine adaptations of air/oxygen devices for heliox delivery.
- To highlight the benefits of FDA-cleared heliox devices.
Main Methods:
- Literature review of heliox administration devices.
- Analysis of device modifications for heliox use.
- Evaluation of risks associated with non-standard device usage.
Main Results:
- Many devices used for heliox administration were not originally designed for this purpose.
- Modifying existing devices for heliox delivery introduces risks and liability.
- Specialized and FDA-cleared devices mitigate risks in heliox administration.
Conclusions:
- Proper device selection is crucial for safe heliox administration.
- Using FDA-cleared devices minimizes risks and liability for healthcare providers.
- The availability of appropriate devices enhances the clinical utility of heliox.
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