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Updated: Aug 8, 2026
Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds
Published on: August 16, 2014
In vitro characteristics of poly(lactic-co-glycolic acid) microspheres incorporating gelatin particles loading basic
Shao-Hong Li1, Shao-Xi Cai, Bing Liu
1Key Laboratory for Biomechanical and Tissue Engineering, State Ministry of Education, College of Bioengineerin, Chongqing University, Chongqing 400030, China.
Aim:
To construct a sustained drug release system for basic fibroblast growth factor (bFGF). With this special system, bFGF can be used to repair an injured peripheral nerve, injured spinal cord, or as a carrier for other drugs that need to be released over a long time.
Methods:
Microsphere composite was prepared by encapsulating bFGF into gelatin particles with poly(lactic-co-glycolic acid) (PLGA) as its outer-coating. The encapsulation was conducted by a phase separation method.
Results:
The average diameter of the gelatin particle-PLGA microsphere composite was 5-18 mum, and bFGF-loading efficiency was up to 80.5%. The bFGF releasing experiment indicated that this new composite system could release bFGF continuously and protect bFGF from denaturation.
Conclusion:
A modified approach was successfully employed to develop a biodegradable system for sustained release of the drug of bFGF in vitro.
