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The relationship between crystalline methamphetamine use and methamphetamine dependence.

Rebecca McKetin1, Erin Kelly, Jennifer McLaren

  • 1National Drug and Alcohol Research Centre, University of New South Wales, Sydney, 2052 NSW, Australia. r.mcketin@unsw.edu.au

Drug and Alcohol Dependence
|May 26, 2006
PubMed
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Crystalline methamphetamine users show higher dependence rates compared to users of other forms. This increased dependence is linked to the crystalline form, even after accounting for drug use history and patterns.

Area of Science:

  • Addiction Research
  • Psychopharmacology
  • Public Health

Background:

  • Investigating methamphetamine dependence severity.
  • Comparing dependence between crystalline and non-crystalline methamphetamine users.
  • Exploring the role of drug use history in methamphetamine dependence.

Purpose of the Study:

  • To determine if crystalline methamphetamine users exhibit greater dependence than users of other forms.
  • To ascertain if methamphetamine use history explains any observed differences in dependence.

Main Methods:

  • Structured interviews with 309 regular methamphetamine users in Sydney, Australia.
  • Assessment of past-year methamphetamine dependence using the Severity of Dependence Scale.
  • Confirmation of crystalline methamphetamine use via photographic identification.

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Main Results:

  • Users of crystalline methamphetamine were significantly more likely to be dependent (61%) than users of other forms (39%).
  • Dependence was associated with injecting/smoking, weekly or more frequent use, >5 years of use, and 'base' methamphetamine use.
  • Crystalline methamphetamine use remained a significant predictor of dependence after adjusting for other use patterns.

Conclusions:

  • Past-year use of crystalline methamphetamine is associated with a higher likelihood of methamphetamine dependence.
  • The findings highlight the distinct addictive potential of crystalline methamphetamine.