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Related Experiment Videos

Penicillin-resistant pneumococci.

K D Allen1

  • 1Department of Microbiology, Whiston Hospital, Prescot, Merseyside.

The Journal of Hospital Infection
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Penicillin-resistant pneumococci are an increasing global health concern due to altered penicillin-binding proteins. Resistance impacts treatment options and necessitates careful antibiotic sensitivity testing.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Penicillin-resistant pneumococci (PRP) emerged in the late 1960s and 1970s, with increasing global prevalence.
  • Resistance mechanisms involve alterations in penicillin-binding proteins, often conferring cross-resistance to other antibiotics.
  • Various serotypes exhibit penicillin resistance, with type 23 being prevalent in the UK.

Purpose of the Study:

  • To review the epidemiology, mechanisms, detection, and management of penicillin-resistant pneumococci.
  • To highlight the challenges in treating infections caused by these resistant strains.
  • To discuss control measures for limiting the spread of resistant pneumococci.

Main Methods:

  • Literature review of studies on penicillin-resistant pneumococci.

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  • Analysis of resistance mechanisms and serotype distribution.
  • Evaluation of diagnostic and therapeutic strategies.

    • Main Results:

    • Penicillin resistance in pneumococci is rising globally, with significant geographical variation.
    • Altered penicillin-binding proteins are the primary mechanism of resistance.
    • Oxacillin disc diffusion is recommended for accurate penicillin sensitivity testing.
    • Treatment decisions depend on resistance levels, alternative sensitivities, and achievable antibiotic concentrations.
    • Children, particularly those recently hospitalized or on antibiotics, show higher carriage rates.
    • Outbreaks have occurred, prompting the suggestion of control measures.

    Conclusions:

    • Penicillin resistance in pneumococci poses a significant clinical challenge.
    • Accurate detection and appropriate treatment selection are crucial.
    • Control strategies are needed to mitigate the spread of resistant strains.