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Polytetrafluoroethylene/polylactide-co-glycolide laminate containing dexamethasone allows delayed adjustable
Jun-Pil Jee1, Ho-Kyung Choung, Chong-Kook Kim
1National Research Lab for Drug and Gene Delivery, College of Pharmacy, Seoul National University, and Seoul National University Boramae Hospital, Korea.
Purpose:
To determine the usefulness of polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate containing dexamethasone in delayed adjustable strabismus surgery.
Methods:
A prospective, masked-observer, controlled study was performed in rabbits. Fifty-two rabbit eyes were divided into three groups. After a recession of the superior rectus muscle (SRM), a PTFE/PLGA containing or not containing dexamethasone or balanced saline solution was applied beneath and over the SRM in the three treatment groups: the PTFE/PLGA-dexamethasone group (the P-D group), the PTFE group (the P group), and the control group (group C). Delayed adjustment was performed once on each SRM at 3 or 5 weeks after surgery by a masked observer. Adjustment lengths, the forces required, and degrees of adhesions were evaluated.
Results:
In the control group, adjustment was possible in no eyes at 3 or 5 weeks after surgery. In group P, adjustment was possible in 6 of 10 eyes at 3 weeks after surgery and in 4 of 9 eyes at 5 weeks after surgery. In group P-D, adjustment was possible in 7 of 9 eyes at 3 and 5 weeks after surgery.
Conclusions:
PTFE/PLGA containing dexamethasone was found to allow delayed adjustment in most eyes for up to 5 weeks after surgery without instillation of anti-inflammatory agent.
