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Diminished macrophage inflammatory response to Staphylococcus aureus isolates exposed to daptomycin versus vancomycin
B Keith English1, Erik M Maryniw, Ajay J Talati
1Department of Pediatrics, University of Tennessee Health Science Center, 38103, USA. kenglish@utmem.edu
Antimicrobial Agents and Chemotherapy
|May 26, 2006
Abstract:
Exposure of any of six clinical isolates of Staphylococcus aureus to daptomycin alone or in combination with vancomycin or oxacillin (compared with vancomycin or oxacillin alone) led to a dampened macrophage inflammatory response with diminished tumor necrosis factor secretion and reduced accumulation of inducible nitric oxide synthase protein.
