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Updated: Aug 8, 2026

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
Published on: December 5, 2020
Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to
Colin S Osborne1, Ingrid Leitner, Bettina Hofbauer
1Infectious Diseases, Novartis Institutes for BioMedical Research, Inc., Cambridge, MA 02139, USA. colin.osborne@novartis.com
Abstract:
We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.
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