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Relationship between aortic calcification and stroke in a mass screening program using a mobile helical computed

Yasutaka Itani1, Shigeru Watanabe, Yoshiaki Masuda

  • 1The Japanese Society of CT Screening, Tokyo, Japan. itani-y@mtg.biglobe.ne.jp

Circulation Journal : Official Journal of the Japanese Circulation Society
|May 26, 2006
PubMed
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Aortic calcification (AoC) detected via mobile CT screening is a strong predictor of cerebral infarction, especially in individuals over 50. Increased calcification segments correlate with higher stroke risk in both men and women.

Area of Science:

  • Cardiovascular Imaging
  • Neurology
  • Public Health Screening

Background:

  • Aortic arch calcification (AoC) on chest X-ray is linked to stroke.
  • The association between AoC detected by mobile CT screening and stroke remains unclear.

Purpose of the Study:

  • To investigate the relationship between aortic calcification (AoC) detected during mass CT screening and cerebral infarction.

Main Methods:

  • Utilized data from 2,618 participants in a mass CT screening for lung cancer and tuberculosis.
  • Analyzed the frequency of AoC in subjects with and without a history of cerebral infarction.
  • Performed logistic regression to assess AoC as a predictor of infarction, adjusting for sex, age, and risk factors.

Main Results:

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  • Aortic calcification (AoC) was significantly more frequent in subjects over 50 with a history of cerebral infarction.
  • AoC emerged as a stronger predictor of infarction than sex, age, or other risk factors.
  • The odds ratio for infarction increased with the number of calcified segments, showing higher risks for men (1.82) and women (2.53).

Conclusions:

  • Detection of AoC during mass chest CT screening is an effective method for assessing cerebral infarction risk.
  • Mobile helical CT screening can identify individuals at elevated risk for stroke based on AoC.