Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Temporal effects of shock wave lithotripsy.

J S Morris1, D A Husmann, W T Wilson

  • 1Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75235.

The Journal of Urology
|April 1, 1991
PubMed
Summary

To minimize kidney damage from extracorporeal shock wave lithotripsy, avoid single high-dose treatments. Multiple smaller doses of shock waves are safer for patients undergoing kidney stone removal.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Olfactory outcomes following biological therapy in chronic rhinosinusitis: a systematic review and meta-analysis.

Rhinology·2025
Same author

The Sparta Science force plate is reliable in assessment of recovery following anterior cruciate ligament reconstruction.

Journal of ISAKOS : joint disorders & orthopaedic sports medicine·2025
Same author

Deficits in muscle strength are not seen following recovery from augmented primary repair of anterior cruciate ligament tears.

Journal of ISAKOS : joint disorders & orthopaedic sports medicine·2023
Same author

Screening for Zinner Syndrome in Patients With a Congenitally Solitary Kidney: Lessons Learned.

The Journal of urology·2023
Same author

Comparable rates of secondary surgery between anterior cruciate ligament repair with suture tape augmentation and anterior cruciate ligament reconstruction.

Journal of experimental orthopaedics·2022
Same author

Retrospective assessment of tolerability and efficacy of zoledronate in the palliative treatment of cancer-bearing dogs.

Australian veterinary journal·2022

Area of Science:

  • Nephrology
  • Urology
  • Biomedical Engineering

Background:

  • Renal parenchymal injury after extracorporeal shock wave lithotripsy (ESWL) is linked to shock wave power and total number.
  • Understanding the impact of dose timing (temporal vs. cumulative) is crucial for optimizing ESWL protocols.

Purpose of the Study:

  • To investigate the renal parenchymal damage caused by different temporal administration patterns of shock waves in a rabbit model.
  • To compare the effects of single high-dose ESWL versus fractionated low-dose ESWL on kidney function and pathology.

Main Methods:

  • Adult female rabbits were assigned to five groups: 1000 shocks (1 session), 2000 shocks (1 session), 2000 shocks (2 sessions), unilateral nephrectomy, or anesthesia control.
  • Renal function was assessed one month post-ESWL via enzymuria (gamma glutamyl transferase, N-acetyl-beta-glucosaminidase).

Related Experiment Videos

  • Renal pathology was evaluated for periglomerular and intratubular fibrosis.

    • Main Results:

    • Persistent enzymuria was observed in rabbits receiving 2000 shocks in a single session.
    • Pathologic studies revealed significantly increased periglomerular and intratubular fibrosis in the single high-dose group compared to fractionated or lower-dose groups (p < 0.01).
    • Fractionated ESWL (2000 shocks in two sessions) resulted in less renal damage than a single session of 2000 shocks.

    Conclusions:

    • Single, high-dose administration of shock waves during lithotripsy can lead to significant renal parenchymal injury.
    • Fractionated ESWL, using multiple smaller doses, is a preferred method to minimize renal damage, especially for hard or large calculi.
    • These findings emphasize the importance of dose fractionation in ESWL to preserve kidney function.