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Updated: Jul 30, 2026

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
Severe limb abnormalities after chorion villus sampling at 56-66 days' gestation
H V Firth1, P A Boyd, P Chamberlain
1Department of Medical Genetics, Churchill Hospital, Oxford, UK.
Abstract:
Among 289 pregnancies in which chorion villus sampling (CVS) was carried out at 56-66 days' gestation, 5 babies with severe limb abnormalities were subsequently identified. 4 had oromandibular-limb hypogenesis syndromes, and the other had a terminal transverse limb reduction defect. This high incidence raises the possibility that CVS was an aetiological factor for these developmental anomalies.
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