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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...

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Updated: Jun 26, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

Validating cancer drug targets.

John D Benson1, Ying-Nan P Chen, Susan A Cornell-Kennon

  • 1Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

Nature
|May 26, 2006
PubMed
Summary
This summary is machine-generated.

Validating cancer drug targets requires demonstrating clinical effectiveness. However, universally accepted criteria for early-stage target validation are still lacking, despite their utility in guiding research.

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Area of Science:

  • Oncology
  • Pharmacology
  • Biomedical Research

Background:

  • True validation of a cancer drug target relies on clinical efficacy of a therapeutic agent acting via that target.
  • Early-stage target validation is desirable to guide drug discovery investments.
  • Current validation studies inform cancer research but lack universal criteria.

Purpose of the Study:

  • To discuss the concept and desirability of early-stage cancer drug target validation.
  • To highlight the gap in established, universal criteria for target validation.
  • To underscore the importance of validation outcomes in cancer research.

Main Methods:

  • Literature review and conceptual analysis of drug target validation principles.
  • Discussion of the relationship between target validation and clinical drug development.
  • Analysis of the current state of validation criteria in cancer research.

Main Results:

  • Clinical effectiveness and on-target action are the ultimate validation metrics for cancer drug targets.
  • Early validation is a practical goal, but lacks standardized, universal criteria.
  • Existing validation studies offer guidance but are not universally defined.

Conclusions:

  • Defining universal criteria for early-stage cancer drug target validation remains an unmet need.
  • While clinical validation is definitive, early indicators are crucial for efficient drug discovery.
  • Further development of standardized validation methodologies is essential for advancing cancer therapeutics.