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Correlation of retention factor of analytes in quaternary solvent mobile phases using the Jouyban-Acree model
J Hanaee1, A Jouyban, M R Rashidi
1Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract:
The Jouyban-Acree model has been used for the mathematical representation of retention factors of phenobarbital, phenytoin and carbamazepine in quaternary aqueous-organic solvent mobile phases. The accuracy of the proposed model is evaluated using average percentage deviation (APD) of experimental and calculated values as an accuracy criterion. The obtained mean and standard deviation of APDs of the model is 4.2 +/- 0.5%. The results showed that the Jouyban-Acree model provided accurate calculations and could be used in practice to speed up the method development process in which quaternary solvent mobile phases are required.
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