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Oblongifolins A-D, polyprenylated benzoylphloroglucinol derivatives from Garcinia oblongifolia
Wafaa Hamed1, Solenn Brajeul, Florence Mahuteau-Betzer
1Institut de Chimie des Substances Naturelles, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
Abstract:
Oblongifolins A-D (2-5), four new polyprenylated 3,4-dihydroxybenzoylphloroglucinol compounds, were isolated from the bark of Garcinia oblongifolia collected in Vietnam. The bark was also found to contain the known compounds camboginol and guttiferone B. Extraction of the leaves gave 2 and camboginol. Details of the structure elucidation of 2-5 and stereochemical comparisons with known natural derivatives of general formula 1a,b are presented. The biological activity of these compounds concerning interactions with tubulin was investigated.
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