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Related Experiment Videos

Miniature bioreactors: current practices and future opportunities.

Jonathan I Betts1, Frank Baganz

  • 1The Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK. jonathan.betts@genzyme.com

Microbial Cell Factories
|May 27, 2006
PubMed
Summary

Miniature bioreactors (MBRs) accelerate bioprocessing through high-throughput parallel cell cultivation. This review explores MBR applications, designs, and integration with automation for efficient process development.

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Area of Science:

  • Biotechnology
  • Bioprocessing Engineering

Background:

  • Miniature bioreactors (MBRs) are an emerging technology designed to enhance the speed and efficiency of bioprocessing.
  • Their high-throughput capability stems from the ability to conduct numerous cell cultivations simultaneously.

Purpose of the Study:

  • To review the applications of MBRs in bioprocessing, including media development, strain improvement, and process optimization.
  • To evaluate different MBR designs based on existing bioreactor platforms (shaken devices, stirred-tank reactors, bubble columns).
  • To discuss the integration of MBRs with automation for comprehensive high-throughput cell cultivation process development.

Main Methods:

  • Review of existing literature and commercialized devices related to miniature bioreactors.
  • Comparative analysis of different MBR designs, highlighting advantages and disadvantages.

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  • Exploration of MBR integration with automated systems.

    • Main Results:

    • MBRs offer significant acceleration in bioprocessing tasks due to parallel cultivation.
    • Various MBR platforms exist, each with specific benefits and drawbacks.
    • Integration with robotics enables fully automated, high-throughput solutions.

    Conclusions:

    • MBRs represent a powerful tool for accelerating bioprocess development and optimization.
    • The choice of MBR design depends on specific application requirements.
    • Automated MBR systems promise to revolutionize cell cultivation process development.