Novel, potent, selective, and orally bioavailable human betaII-tryptase inhibitors
David Sperandio1, Vincent W-F Tai, Julia Lohman
1Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA. david.sperandio@gilead.com
Bioorganic & Medicinal Chemistry Letters
|May 27, 2006
Abstract:
The synthesis of novel [1,2,4]oxadiazoles and their structure-activity relationship (SAR) for the inhibition of tryptase and related serine proteases is presented. Elaboration of the P'-side afforded potent, selective, and orally bioavailable tryptase inhibitors.
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