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14-3-3 proteins as potential oncogenes

Guri Tzivion1, Vinita Singh Gupta, Ludmila Kaplun

  • 1Karmanos Cancer Institute and Department of Pathology, Wayne State University, Detroit, MI 48201, USA. tziviong@karmanos.org

Seminars in Cancer Biology
|May 27, 2006
PubMed

Insights

14-3-3 proteins regulate key cell pathways and are implicated in cancer. This review explores their role in cancer development and progression, highlighting potential therapeutic targets.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • 14-3-3 proteins are conserved regulators of essential cellular processes.
  • Over 200 target proteins are known, influencing signaling, cell survival, and apoptosis.
  • 14-3-3 proteins interact with oncogenes and tumor suppressors.

Purpose of the Study:

  • To review the current understanding of 14-3-3 proteins in human cancer.
  • To discuss the mechanisms by which 14-3-3 proteins contribute to cancer.
  • To identify potential points of intervention for cancer therapy.

Main Methods:

  • Literature review of studies on 14-3-3 proteins and cancer.
  • Analysis of reported interactions between 14-3-3 proteins and cancer-related genes.
  • Synthesis of findings on the functional roles of 14-3-3 proteins in tumorigenesis.

Main Results:

  • 14-3-3 proteins are frequently dysregulated in various cancers.
  • They influence multiple hallmarks of cancer, including proliferation and survival.
  • Specific 14-3-3 isoforms may have distinct roles in different cancer types.

Conclusions:

  • 14-3-3 proteins represent a significant factor in cancer development and progression.
  • Understanding their regulatory networks offers potential for novel cancer treatments.
  • Targeting 14-3-3 interactions could be a promising therapeutic strategy.

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