Embryo transfer from goats seropositive for caprine arthritis-encephalitis virus

Area of Science:

• Veterinary Virology
• Reproductive Immunology
• Small Ruminant Health

Background:

• Caprine arthritis-encephalitis virus (CAEV) causes significant economic losses in goat populations worldwide.
• Vertical transmission of CAEV from infected does to their offspring is a major concern for disease control.
• Understanding transmission routes is crucial for developing effective prevention strategies.

Purpose of the Study:

• To investigate the potential for CAEV transmission through uterine flushings and embryo transfer in goats.
• To determine if CAEV can be isolated from reproductive tissues and colostrum of infected does.
• To assess the risk of CAEV transmission to seronegative recipients and their offspring.

Main Methods:

• CAEV isolation attempts from uterine flushings of superovulated, seropositive does.
• Embryo transfer from seropositive does to seronegative recipients.
• Serological monitoring of recipients and offspring.
• Virus isolation from colostrum and placental tissues post-parturition.

Main Results:

• CAEV was not isolated from uterine flushings of infected does.
• No evidence of CAEV infection was found in colostrum or placental tissues.
• All recipient does and their offspring remained seronegative throughout the study period.

Conclusions:

• Embryo transfer may be a safe method for preventing CAEV transmission in goats.
• Vertical transmission via uterine fluids or early placental contact appears limited under these conditions.
• Further research is warranted to confirm the efficacy of assisted reproductive technologies for CAEV eradication programs.