Oxytocin-induced biochemical changes in cervical mucus of the goat

This study was conducted to investigate the effects of oxytocin administration on plasma progesterone concentration and cervical mucus content of protein and acid and alkaline phosphatase activity in the goat. Oxytocin administered to goats (100 IU, S.C. daily) between Days 3 and 6 of estrous cycle induced estrus and resulted in a corresponding decrease in the levels of plasma progesterone, as well as in the contents of protein and in acid and alkaline phosphatase in the cervical mucus. Administration of indomethacin (10 mg/kg body weight, S.C.) inhibited oxytocin-induced estrus and changes in progesterone, protein and enzymes. It is suggested that oxytocin-induced changes are mediated via the production and release of prostaglandin F2alpha (PGF2alpha).