Distribution of alpha-1 and alpha-2 binding sites in the rat locus coeruleus

¹Laboratoire de Neuropharmacologie Moléculaire CNRS-UCB UMR 105, Institut des Sciences Pharmaceutiques et Biologiques, Faculté de Pharmacie, Lyon, France.

|February 1, 1991

Abstract:

Precise anatomical distribution of alpha-1 and alpha-2 adrenergic binding sites has been investigated in the rat locus coeruleus (LC) using quantitative radioautography of brain sections incubated with 3H-prazosin or 3H-idazoxan. Distribution patterns of 3H-prazosin (alpha-1 sites) and 3H-idazoxan (alpha-2 sites) were heterogeneous and different along a postero-anterior axis in the LC. Comparison between distribution of alpha-2 binding sites and noradrenergic (NA) cellular density suggests that at least a fraction of these sites might be localized on NA perikarya or dendrites in this structure. Quantitative estimations of the binding parameters along this postero-anterior axis in the LC have revealed that the heterogeneous distributions of alpha-1 and alpha-2 binding sites are due not only to variations in the maximal densities of sites but also to variations in the affinities of these sites for their respective ligand.

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Distribution of alpha-1 and alpha-2 binding sites in the rat locus coeruleus

Abstract:

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