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Developmental mouse brain gene expression maps.

Craig L Brumwell1, Tom Curran

  • 1Developmental Neurobiology, St Jude Children's Research Hospital, 332 N Lauderdale, Memphis, TN 38105-2729, USA.

The Journal of Physiology
|May 27, 2006
PubMed
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This study surveys mouse brain gene expression databases, focusing on embryonic development. Comparing embryonic and adult gene patterns aids understanding neurodevelopment and gene function.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Bioinformatics

Background:

  • Brain gene expression databases offer valuable neuroscience data.
  • Existing databases predominantly focus on adult mouse models.
  • Limited resources are available for embryonic brain development gene expression.

Purpose of the Study:

  • To survey major mouse gene expression databases for the developing brain.
  • To highlight the importance of comparing embryonic neurodevelopment with adult gene expression.
  • To facilitate future studies by mapping gene expression from embryo to adult.

Main Methods:

  • Survey of existing mouse gene expression databases.
  • Focus on data relevant to embryonic brain development.
  • Utilizing high-throughput in situ hybridization data.

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Main Results:

  • Identified key databases for embryonic mouse brain gene expression.
  • Emphasized the utility of high-throughput in situ hybridization for data generation.
  • Highlighted the need for comprehensive embryonic brain gene expression atlases.

Conclusions:

  • Comparing embryonic and adult gene expression is crucial for understanding neurodevelopment.
  • Gene expression databases are essential tools for neuroscience research.
  • Mapping all genes in the developing and adult brain will advance future studies.