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Appendiceal goblet cell carcinoids: a clinicopathological and immunohistochemical study
N H Anderson1, J E Somerville, C F Johnston
1Department of Histopathology, Royal Victoria Hospital, Belfast, UK.
Histopathology
|January 1, 1991
Summary
Goblet cell carcinoids, rare appendix tumors, show varied outcomes based on extent. Early diagnosis and localized tumors correlate with better survival rates in this study.
Area of Science:
- Gastroenterology
- Surgical Pathology
- Oncology
Background:
- Goblet cell carcinoids are distinctive, uncommon tumors originating in the appendix.
- These neuroendocrine tumors present unique diagnostic and prognostic challenges.
Purpose of the Study:
- To review clinical presentation, treatment, and outcomes of goblet cell carcinoids.
- To analyze histopathological and immunohistochemical features of these appendiceal tumors.
Main Methods:
- Retrospective review of 11 goblet cell carcinoid cases diagnosed between 1976 and 1990.
- Analysis of patient demographics, tumor stage at presentation, treatment strategies, and follow-up data.
- Immunohistochemical staining for neuron-specific enolase, chromogranin A, protein gene product 9.5, substance P, glucagon-like immunoreactivity, and pancreatic polypeptide.
Main Results:
- The mean age of presentation was 58 years, with a female predominance (8:3 ratio).
- Seven patients had localized disease (appendix/mesoappendix), with six achieving disease-free survival.
- Four patients had extensive disease; two died from metastases or obstruction, while two had uncertain outcomes.
- All tumors expressed neuroendocrine markers; four showed unusual positivity for pancreatic polypeptide.
Conclusions:
- Localized goblet cell carcinoids have a favorable prognosis with high survival rates.
- Advanced or metastatic goblet cell carcinoids are associated with poorer outcomes and potential complications.
- The immunohistochemical profile, including pancreatic polypeptide positivity, may offer insights into tumor behavior.