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Updated: Aug 8, 2026

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
Published on: June 23, 2026
Design of targeting ligands in medicinal inorganic chemistry
Tim Storr1, Katherine H Thompson, Chris Orvig
1Medicinal Inorganic Chemistry Group, Chemistry Department, The University of British Columbia, Vancouver, BC, CanadaV6T-1Z1. tstorr@stanford.edu
Abstract:
This tutorial review will highlight recent advances in medicinal inorganic chemistry pertaining to the use of multifunctional ligands for enhanced effect. Ligands that adequately bind metal ions and also include specific targeting features are gaining in popularity due to their ability to enhance the efficacy of less complicated metal-based agents. Moving beyond the traditional view of ligands modifying reactivity, stabilizing specific oxidation states, and contributing to substitution inertness, we will discuss recent work involving metal complexes with multifunctional ligands that target specific tissues, membrane receptors, or endogenous molecules, including enzymes.
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