Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lung dendritic cells and the inflammatory response.

Mitchell H Grayson1

  • 1Division of Allergy and Immunology, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA. mgrayson@wustl.edu

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|May 30, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-cell RNA sequencing of hematopoietic and non-hematopoietic cells defines a distinct signature in atopic and NRG1 mouse lung.

Scientific reports·2026
Same author

Gingipain proteases from the bacterium <i>Porphyromonas gingivalis</i> confer protection against airway viral infection.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Everything immunodeficiency.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same author

Crystal ball: Predictions for urticaria treatment and lung function trajectories.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same author

Open access is essential for research funded by the National Institutes of Health (NIH).

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same author

2025 American College of Allergy, Asthma and Immunology Annals fellow-in-training award winners: The future of allergy and immunology.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2025

Dendritic cells initiate and regulate lung immune responses. Targeting these cells offers potential therapies for allergic and asthmatic diseases.

Area of Science:

  • Immunology
  • Pulmonology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are key antigen-presenting cells strategically located in the respiratory tract.
  • They play a critical role in initiating adaptive immunity and T-cell responses.
  • DCs also regulate ongoing immune responses, a focus of current research.

Purpose of the Study:

  • To review the function of conventional and plasmacytoid dendritic cells in lung immunity.
  • To discuss their role in inducing and modulating immune responses to allergens and pathogens.

Main Methods:

  • Literature review of studies on dendritic cells in rodent and human lungs.
  • PubMed/MEDLINE search using keywords: dendritic cell, antigen-presenting cell, viral airway disease, asthma, allergy, atopy.

Related Experiment Videos

  • Inclusion of author's expertise in study selection.

    • Main Results:

    • Dendritic cells are optimally positioned to detect foreign proteins in the airways.
    • They are essential for initiating antigen-specific T-cell responses.
    • DCs are involved in regulating both the development and progression of immune responses.

    Conclusions:

    • Conventional and plasmacytoid dendritic cells are pivotal in initiating and modulating lung immune responses.
    • Their unique position suggests potential for therapeutic interventions in allergic and asthmatic conditions.