In vitro inhibition of human influenza A virus replication by chloroquine
Eng Eong Ooi1, Janet Seok Wei Chew, Jin Phang Loh
1Defence Medical and Environmental Research Institute, DSO National Laboratories, 27 Medical Drive, #09-01, 117510, Singapore. oengeong@dso.org.sg
Abstract:
Chloroquine is a 9-aminoquinolone with well-known anti-malarial effects. It has biochemical properties that could be applied to inhibit viral replication. We report here that chloroquine is able to inhibit influenza A virus replication, in vitro, and the IC50s of chloroquine against influenza A viruses H1N1 and H3N2 are lower than the plasma concentrations reached during treatment of acute malaria. The potential of chloroquine to be added to the limited range of anti-influenza drugs should be explored further, particularly since antiviral drugs play a vital role in influenza pandemic preparedness.
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