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Altered nociceptive response in ADAM11-deficient mice
Eiki Takahashi1, Koji Sagane, Takeshi Nagasu
1Tsukuba Research Laboratory, Eisai Co. Ltd., 5-1-3, Tokodai, Tsukuba, Ibaraki, 300-2635, Japan. e2-takahashi@hhc.eisai.co.jp
Brain Research
|May 30, 2006
Summary
Mice lacking A Disintegrin And Metalloprotease 11 (ADAM11) show normal pain responses in some tests but reduced responses in others. This suggests ADAM11 influences pain perception and inflammation.
Area of Science:
- Neuroscience
- Molecular Biology
- Immunology
Background:
- A Disintegrin And Metalloprotease 11 (ADAM11) is a cell adhesion-related molecule.
- The role of ADAM11 in pain modulation and inflammatory processes is not fully understood.
Purpose of the Study:
- To investigate the function of ADAM11 in pain perception and inflammatory responses.
- To determine the involvement of ADAM11 in pain transmission pathways.
Main Methods:
- Utilized knockout mice lacking the ADAM11 protein.
- Assessed pain responses using the von Frey test, hot plate test, formalin paw test, and acetic acid writhing test.
Main Results:
- Mice lacking ADAM11 exhibited normal responses in the von Frey and hot plate tests.
- Reduced pain responses were observed in the formalin paw and acetic acid writhing tests in ADAM11-deficient mice.
- These findings suggest a role for ADAM11 in specific pain pathways.
Conclusions:
- ADAM11 plays a significant role in pain transmission.
- ADAM11 is implicated in the regulation of inflammatory mechanisms affecting pain perception thresholds.
