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Related Experiment Videos

Oxygen availability during hypothermic cardiopulmonary bypass.

A Fisher, P Foëx, P M Emerson

    Critical Care Medicine
    |May 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    Hypothermia during cardiopulmonary bypass significantly reduces oxygen availability by shifting the oxyhemoglobin dissociation curve. This limits hemoglobin

    Area of Science:

    • Cardiovascular Surgery
    • Physiology
    • Blood Transfusion

    Background:

    • Cardiopulmonary bypass (CPB) often involves hypothermia, affecting oxygen transport.
    • The oxyhemoglobin dissociation curve (ODC) indicates hemoglobin's oxygen affinity.
    • Blood storage solutions like ACD and CPD can influence ODC parameters.

    Purpose of the Study:

    • To assess oxygen availability and hemoglobin's functional capacity during CPB under hypothermic and normothermic conditions.
    • To investigate the impact of different blood storage solutions (ACD vs. CPD) on oxygen transport during CPB.

    Main Methods:

    • Studied 22 patients undergoing CPB, divided into hypothermic and normothermic phases.
    • Measured P50 values to assess ODC shifts.
    • Calculated oxygen uptake using arterial-venous oxygen content differences (avDO2) and blood flow.

    Related Experiment Videos

  • Analyzed acid-base balance and 2,3-diphosphoglycerate (2,3-DPG) concentrations.

    • Main Results:

    • Hypothermia caused a significant leftward shift in the ODC (P50 decreased from 25.9 to 15.6 mmHg).
    • Oxygen uptake was significantly lower during hypothermic bypass (65 ml/min) compared to rewarming (121 ml/min).
    • CPD blood group showed increased oxygen availability during rewarming, linked to higher 2,3-DPG levels.
    • Functional hemoglobin capacity was markedly reduced (4.2 g/100 ml) during hypothermic bypass.

    Conclusions:

    • Hypothermia during CPB impairs oxygen unloading due to a left-shifted ODC, despite reduced metabolic demand.
    • Oxygenation reserves are minimal during the hypothermic phase of CPB.
    • CPD blood may offer advantages during rewarming due to better oxygen availability, potentially related to 2,3-DPG concentrations.