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Related Experiment Videos

Mouse genetic models in alcohol research.

Beth Bennett1, Chris Downing, Clarissa Parker

  • 1Institute for Behavioral Genetics, 447 UCB, Boulder, CO 80309-0447, USA. bennettb@colorado.edu

Trends in Genetics : TIG
|May 30, 2006
PubMed
Summary

Mouse genetic models are crucial for studying alcoholism, offering insights into its complex components. Ongoing research using these models is identifying genes linked to alcohol-related behaviors.

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Area of Science:

  • Neuroscience
  • Genetics
  • Pharmacology

Background:

  • Alcoholism is a complex human disorder with multifaceted components.
  • Animal models, particularly rodents, are valuable tools for studying alcoholism.
  • No single animal model perfectly replicates all aspects of human alcoholism.

Purpose of the Study:

  • To review widely used mouse genetic models in alcohol research.
  • To highlight the utility of genetically defined mouse strains for studying alcoholism.
  • To discuss recent advances in identifying genes associated with alcoholism.

Main Methods:

  • Review of existing literature on mouse genetic models in alcohol research.
  • Focus on genetically defined strains and stocks of mice.

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  • Examination of genetic, physiologic, behavioral, and pharmacological studies.

    • Main Results:

    • Genetically defined mouse strains offer advantages for studying various components of alcoholism.
    • Numerous genomic regions linked to alcohol-related behaviors have been identified.
    • New methods are aiding in the identification of quantitative trait genes.

    Conclusions:

    • Mouse genetic models are essential for advancing our understanding of alcoholism.
    • Continued research is expected to identify more genes underlying alcoholism.
    • These genetic insights hold promise for future therapeutic strategies.