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Updated: Aug 8, 2026
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Published on: December 31, 2015
Transcervical intrapartum amnioinfusion for preterm premature rupture of the membranes
Alberto Puertas1, Pilar Tirado1, Isabel Pérez1
1Obstetrics and Gynaecology Service, Virgen de las Nieves University Hospital, Avenida Fuerzas Armadas s/n, 18014 Granada, Spain.
Objectives:
To investigate the effect of transcervical amnioinfusion on the management of labour and neonatal outcomes in preterm premature rupture of the membranes.
Study Design:
This clinical trial included 86 patients with premature rupture of the membranes between weeks 27 and 35 of gestation. Patients were randomly assigned to receive amnioinfusion via a two-way catheter or to the control group. Clinical management was otherwise the same in both groups.
Results:
Amnioinfusion decreased the frequency of variable decelerations in fetal heart rate (27.9% versus 53.5%, p<0.05) and the rate of obstetric interventions motivated by nonreassuring fetal status (13.6% versus 52.4%, p<0.05). At delivery, pH values were significantly higher in the treatment group than in the conventionally managed control group (median 7.29 versus 7.27).
Conclusions:
Intrapartum transcervical amnioinfusion for preterm premature rupture of the membranes reduced the number of interventions needed because of nonreassuring fetal status, and improved neonatal gasometric values without increasing maternal or fetal morbidity.
