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Related Experiment Videos

Accelerated partial breast irradiation using proton beams: Initial dosimetric experience.

Alphonse G Taghian1, Kevin R Kozak, Angela Katz

  • 1Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. ataghian@partners.org

International Journal of Radiation Oncology, Biology, Physics
|May 30, 2006
PubMed
Summary
This summary is machine-generated.

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Proton radiotherapy for accelerated partial breast irradiation (3D-CPBI) offers excellent tumor coverage and spares normal tissues. This technique is feasible and reduces irradiated breast tissue compared to photon therapy.

Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Physics

Background:

  • Proton radiotherapy offers unique dosimetric advantages for normal tissue sparing.
  • Accelerated partial breast irradiation (APBI) is an alternative to whole-breast irradiation (WBI).
  • Three-dimensional conformal proton beam radiation therapy (3D-CPBI) combines these approaches.

Purpose of the Study:

  • To present initial clinical experience with proton 3D-CPBI.
  • To evaluate dosimetric outcomes and feasibility.
  • To assess normal tissue sparing and compare with photon-based methods.

Main Methods:

  • 25 patients with early-stage breast cancer received proton 3D-CPBI (32 CGE in 4 fractions, twice daily).
  • Tumors were ≤2 cm with negative axillary nodes.

Related Experiment Videos

  • One to three proton beams were used for treatment planning.

    • Main Results:

    • Excellent planning target volume (PTV) coverage (median 100% receiving 95% dose) and homogeneity were achieved.
    • Reduced irradiation of nontarget breast tissue (median 23% receiving 50% dose).
    • Minimal dose to ipsilateral lung (median 0-2% for 5-20 CGE) and no dose to contralateral lung or heart.

    Conclusions:

    • Proton 3D-CPBI is technically feasible, achieving excellent PTV coverage and normal tissue sparing.
    • It significantly reduces irradiated nontarget breast tissue volume compared to photon 3D-CPBI.
    • Proton therapy may become an attractive option for APBI as it becomes more accessible.