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Published on: April 1, 2019
Leukotriene C4 synthase A-444C gene polymorphism in patients with allergic rhinitis
Hatice Gülçin Eskandari1, Murat Unal, Ozlem Görüroğlu Oztürk
1Department of Biochemistry, Mersin University School of Medicine, Mersin, Turkey. geskandari@hotmail.com
Objective:
To determine the frequency of leukotriene C4 synthase A-444C polymorphism in allergic rhinitis patients.
Study Design And Setting:
A prospective, randomized, case-controlled study. Blood samples were obtained from 85 patients with allergic rhinitis and 95 healthy individuals. After the extraction of DNA from the blood samples, the leukotriene C4 synthase A-444C polymorphism was studied by a real-time polymerase chain reaction method.
Results:
The AC and CC genotype frequencies were statistically higher in the study group (P = 0.048 and P = 0.037, respectively). In addition, the AC polymorphism carried an increased risk of developing allergic rhinitis (odds ratio = 2.18, 95% confidence interval, 1.173-4.053, P = 0.014).
Conclusion:
The C allele of the leukotriene C4 synthase gene increases the risk of developing allergic rhinitis.
Significance:
The leukotriene C4 synthase A-444C gene polymorphism is important in susceptibility to allergic rhinitis and this is the first study of this gene polymorphism in allergic rhinitis.
Ebm Rating:
B-3b.
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