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Cystatin C reference values and aging
Agostino Ognibene1, Edoardo Mannucci, Anna Caldini
1Central Laboratory of Clinical Biochemistry, Careggi Hospital, Viale Morgagni 85, 50139 Florence, Italy. ognibenea@ao-careggi.toscana.it
Clinical Biochemistry
|May 30, 2006
Summary
This study establishes age-adjusted reference values for serum cystatin C (CysC), a key biomarker. Age significantly impacts CysC levels, necessitating tailored reference intervals for accurate clinical interpretation.
Area of Science:
- Clinical Chemistry
- Biomarker Research
- Geriatric Medicine
Background:
- Serum cystatin C (CysC) is a promising biomarker for kidney function.
- Aging is known to influence various physiological parameters, potentially affecting CysC levels.
- Establishing accurate reference ranges is crucial for reliable diagnostic interpretation.
Purpose of the Study:
- To determine age-specific reference values for serum cystatin C (CysC).
- To investigate the impact of aging on CysC levels in a diverse population.
- To provide updated reference intervals for CysC based on age.
Main Methods:
- Analysis of laboratory parameters from 258 men and 396 women.
- Collection of detailed personal and family medical history.
- Multivariate linear regression analysis adjusted for serum creatinine (SCr).
Main Results:
- Serum cystatin C (CysC) demonstrated a significant correlation with age in both sexes.
- Age-related reference intervals for CysC were established: <0.95 mg/L for individuals under 45 years and <1.20 mg/L for those over 45 years.
- The correlation remained significant after adjusting for SCr.
Conclusions:
- Age-adjusted reference values for CysC should be considered in clinical practice.
- The findings highlight the importance of age in interpreting CysC results.
- Careful consideration of age-specific CysC reference intervals is recommended for accurate patient assessment.