Cystatin C reference values and aging
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Published on: April 13, 2018
Agostino Ognibene1, Edoardo Mannucci, Anna Caldini
1Central Laboratory of Clinical Biochemistry, Careggi Hospital, Viale Morgagni 85, 50139 Florence, Italy. ognibenea@ao-careggi.toscana.it
Objectives:
The aim of this study was to determine the reference values for serum cystatin C (CysC) with a particular focus on the effect of aging.
Design And Methods:
The study was performed on a consecutive series of subjects (258 men and 396 women). Laboratory parameters and a detailed personal and family medical history were collected.
Results:
CysC showed a significant correlation with age in both sexes, which was confirmed with multivariate linear regression after adjustment for SCr (serum creatinine). Age-related reference intervals were established for cystatin C (<45 years, <0.95 mg/L and >45 years, <1.20 mg/L).
Conclusions:
The use of CysC reference values adjusted for age should be carefully taken into consideration.
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