Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Dynamic performance of accommodating intraocular lenses in a negative feedback control system: a simulation-based

Clifton M Schor¹, Shrikant R Bharadwaj, Christopher D Burns

¹Vision Science group, School of Optometry, University of California at Berkeley, Berkeley, CA 94720-2020, USA. schor@socrates.berkeley.edu

Computers in Biology and Medicine

|May 30, 2006

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reduced Image Quality Impairs Monocular Blur-Driven Accommodation in Keratoconus.

Investigative ophthalmology & visual science·2026

Same author

Interocular mismatches of high-order wavefront aberrations impair stereoacuity following refractive surgeries by reducing the disparity signal quality.

Optometry and vision science : official publication of the American Academy of Optometry·2026

Same author

Assessment of eye movement endurance using the OculoMotor Assessment Tool: A replication study on young Indian adults.

Optometry and vision science : official publication of the American Academy of Optometry·2026

Same author

Characterization of the Functional Transient Receptor Potential Vanilloid Channels 1 to 4 in Human Corneal Endothelial Cells.

Investigative ophthalmology & visual science·2026

Same author

The Impact of Induced Optical Blur on Monocular and Binocular Depth-Related Visuomotor Task Performance.

Investigative ophthalmology & visual science·2025

Same author

Loss of retinal stem cell reserve and lipofuscin accumulation accelerates cone-rod degeneration and replicates Stargardt disease in abca4b null zebrafish.

Scientific reports·2025

Simulations show accommodating intraocular lenses (A-IOLs) can cause visual instability due to material properties. Adapting neural control of ocular accommodation is crucial for stable vision with A-IOLs.

Area of Science:

Ophthalmology
Biomedical Engineering
Computational Neuroscience

Background:

The natural ocular lens hardens with age, impairing focus.
Accommodating intraocular lenses (A-IOLs) aim to restore focus by mimicking natural lens dynamics.

Purpose of the Study:

To simulate the dynamic performance and stability of A-IOLs.
To investigate the impact of A-IOL material properties on visual dynamics.
To determine the role of neural control adaptation in A-IOL stability.

Main Methods:

Developed a dynamic model of ocular accommodation.
Simulated A-IOL performance using biomechanical properties of younger eye materials in an older eye model.
Analyzed simulation results for overshoots, oscillations, and stability.

Related Experiment Videos

Main Results:

A-IOLs with younger eye biomechanical properties in older eyes exhibited overshoots and oscillations.
Decreased visco-elasticity of A-IOL materials was linked to dynamic instability.
Adaptation of neural control properties (phasic and tonic) restored stable A-IOL dynamics.

Conclusions:

Neural control recalibration is essential for stable dynamic accommodation with A-IOLs.
Understanding A-IOL biomechanics and neural interactions is key for effective lens design.
An interactive web-model is available for exploring A-IOL dynamics.