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Updated: Aug 8, 2026

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
Chromium picolinate improves insulin sensitivity in obese subjects with polycystic ovary syndrome
Michael L Lydic1, Margaret McNurlan, Shirley Bembo
1Department of Obstetrics, Gynecology, and Reproductive Medicine, Division of Reproductive Endocrinology, Stony Brook University Hospital, State University of New York-Stony Brook School of Medicine, 1794-8091, USA. mlydic@notes2.cc.sunysb.edu
Abstract:
Trivalent chromium (1000 microg), as chromium picolinate, given without change in diet or activity level, caused a 38% mean improvement in glucose disposal rate in five obese subjects with polycystic ovary syndrome who were tested with a euglycemic hyperinsulinemic clamp technique. This suggests that chromium picolinate, an over-the-counter dietary product, may be useful as an insulin sensitizer in the treatment of polycystic ovary syndrome.
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