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Updated: Aug 8, 2026

Murine Model for Parkinson's Disease: from 6-OH Dopamine Lesion to Behavioral Test
Published on: January 15, 2010
Monomelic parkinsonian tremor caused by contralateral substantia nigra stroke
1Department of Neurology, University of Iowa College of Medicine, Iowa, USA. pedro-gonzalez-alegre@uiowa.edu
Abstract:
Patients with Parkinson's disease have been frequently classified by their most prominent symptoms into tremor-predominant and akinetic/rigid variants. A few pathological studies have suggested that these different phenotypes represent topographical differences in nigral pathology. A patient is described in whom a medial substantia nigra stroke led to contralateral lower extremity parkinsonian tremor, providing a clinical-pathological correlation of this tremor, indicating a somatotopic organization of the substantia nigra and supporting the central generator hypothesis of parkinsonian tremor.
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