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Coronary sinus thermography in idiopathic dilated cardiomyopathy: correlation with systemic inflammation and left

Konstantinos Toutouzas1, Pavlos Stougiannos, Maria Drakopoulou

  • 1First Department of Cardiology, Hippokration Hospital, Athens Medical School, Athens, Greece. ktoutouz@otenet.gr

European Journal of Heart Failure
|May 30, 2006
PubMed

Insights

Patients with dilated cardiomyopathy (DCM) show increased myocardial heat production, measured by coronary sinus (CS) blood temperature. This temperature elevation correlates with reduced ejection fraction but not systemic inflammation.

Area of Science:

  • Cardiology
  • Biomedical Engineering

Background:

  • Heart failure is associated with elevated myocardial heat production.
  • Coronary sinus (CS) thermography offers a novel approach to assess left ventricular heat generation.

Purpose of the Study:

  • To determine if CS blood temperature is elevated in idiopathic dilated cardiomyopathy (DCM) patients compared to controls.
  • To investigate the correlation between CS blood temperature, ejection fraction (EF), and systemic inflammatory markers.

Main Methods:

  • Utilized a novel thermography catheter for temperature measurements in 25 DCM patients and 22 healthy controls.
  • Defined temperature difference (DeltaT) as CS minus right atrial (RA) blood temperature.
  • Measured C-reactive protein (CRP) levels as an indicator of systemic inflammation.

Main Results:

  • DeltaT was significantly higher in DCM patients (0.25±0.09°C) than in controls (0.14±0.07°C).
  • A significant inverse correlation was found between DeltaT and EF in DCM patients (R=0.43).
  • Patients with high CRP levels (< or =1 mg/dL) exhibited lower DeltaT (0.21±0.06°C) compared to those with low CRP (0.30±0.08°C).

Conclusions:

  • Myocardial heat production is increased in DCM patients, as indicated by elevated CS blood temperature.
  • Increased CS blood temperature in DCM correlates with impaired ejection fraction.
  • No significant correlation was observed between elevated myocardial heat production and systemic inflammatory activation in DCM.
Abstract

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