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Updated: Aug 8, 2026

In Vivo Imaging Uncovers the Migratory Behavior of Leukocytes within the Joints
Published on: December 9, 2025
From ubiquitous antigens to joint-specific inflammation: could local vascular permeability be the missing link?
Costantino Pitzalis1, Toby Garrood
1Rheumatology Unit, King's College London School of Medicine, London SE1 9RT, UK. costantino.pitzalis@kcl.ac.uk
Abstract:
The mechanisms underlying organ-specific autoimmune diseases are incompletely understood. In particular, it is still unclear how autoantibodies, often against ubiquitous antigens, can cause pathology preferentially in certain tissues. Recently, Binstadt and colleagues, using observations in the K/BxN murine arthritis model, suggested novel pathways underlying the site-specific localization of inflammation driven by immune complexes. In this commentary, we discuss these findings, the problems related to their general applicability and the implications for future research.
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