Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional circuitry underlying visual neglect.

R Jarrett Rushmore1, Antoni Valero-Cabre, Stephen G Lomber

  • 1Laboratory of Cerebral Dynamics, Plasticity and Rehabilitation Department of Anatomy and Neurobiology, Boston University School of Medicine Boston, MA 02118, USA. rushmore@bu.edu

Brain : a Journal of Neurology
|May 30, 2006
PubMed
Summary

Visuospatial neglect involves reduced neural activity in damaged brain areas and increased activity in the superior colliculus. Therapies targeting superior colliculus activity may effectively treat neglect.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Crossmodal plasticity in core auditory cortex following deafness: An evaluation of evidence for and against.

Hearing research·2026
Same author

Connectional neuroanatomy of U-fibers in the rhesus monkey brain.

bioRxiv : the preprint server for biology·2026
Same author

Identifying biomarkers of deafness-induced cerebral plasticity using MRI.

NeuroImage·2026
Same author

Segregated encoding of auditory and visual information in EEG oscillations.

Journal of neuroscience methods·2026
Same author

Assessment of neural and MAP level asymmetries in a large cohort of children with bilateral cochlear implants.

Hearing research·2026
Same author

Time course of visual plasticity following adult-onset deafness.

Scientific reports·2026

Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Visuospatial neglect is a neurological syndrome from unilateral brain damage.
  • It causes an inability to attend to stimuli in the contralesional hemifield.
  • A leading theory suggests hemispheric inhibition contributes to neglect.

Purpose of the Study:

  • To test the theory of interhemispheric inhibition in neglect.
  • To assess neural activity changes during neglect using 2-deoxyglucose (2DG).
  • To identify brain structures involved in neglect mechanisms.

Main Methods:

  • Induced neglect via cooling deactivation or lesions in cats.
  • Measured 2DG uptake in cortical and midbrain structures.
  • Assessed 2DG uptake changes when neglect was reversed.

Related Experiment Videos

Main Results:

  • Neglect correlated with decreased 2DG uptake in ipsilateral regions.
  • Increased 2DG uptake was observed in the contralateral superior colliculus (SC).
  • Reversing neglect reduced contralateral 2DG uptake.

Conclusions:

  • Data support theories of mutually suppressive interhemispheric mechanisms.
  • These mechanisms operate at the superior colliculus (SC) level, not cortex.
  • Therapies should aim to decrease SC neural activity contralateral to brain damage.