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Updated: Aug 8, 2026

Burn Injury-Induced Pain and Depression-Like Behavior in Mice
Published on: September 29, 2021
Personality and the association of pain and depression
Sarah K Calabrese1, Jeffrey M Lyness, Silvia Sörensen
1Department of Clinical Psychology, The George Washington University, Washington, DC, USA.
Objectives:
The objectives of this study were to test the hypotheses that pain is associated with depression independent of personality and that neuroticism moderates this association.
Method:
Multiple regression analyses were conducted in a group of 404 older primary care patients assessed with validated measures.
Results:
Bodily pain was independently associated with depression. Neuroticism moderated the associations between pain and both depressive symptom severity and major depression, albeit not independent of overall medical burden; the relationships were stronger in subjects with lower neuroticism scores.
Conclusions:
The association of bodily pain with depression may be greater in those previously at lower risk on account of low neuroticism.
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