Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Parturition in the rat: a physiological pain model.

Gwénaëlle Catheline1, Bastien Touquet, Jean-Marie Besson

  • 1Received from Ecole Pratique des Hautes Etudes, Laboratoire de Neurobiologie Intégrative et Adaptative INSERM U378, Bordeaux, France. g.catheline@imf.u-bordeaux2.fr

Anesthesiology
|May 30, 2006
PubMed
Summary

Labor pain in rats involves specific behaviors linked to uterine contractions. Epidural morphine effectively reduced these behaviors and associated spinal neuronal activity, suggesting the rat is a useful model for studying labor pain mechanisms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Memory Performance in Adolescents Living With Obesity: Brain Activation During Encoding and Retrieval in a Case-Control Study.

Obesity science & practice·2026
Same author

Heterogeneous trajectories of executive function in clinical Alzheimer's disease: Results from the 3C study.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

Hallmarks of healthy cognitive aging: Inter-individual differences in aging trajectories.

Ageing research reviews·2026
Same author

Ultra-high resolution multimodal MRI densely labelled holistic structural brain atlas.

Scientific reports·2026
Same author

Impact of seasons and temperatures on the sleep-wake cycle in a French elderly rural population.

Sleep medicine·2025
Same author

DeepCERES: A deep learning method for cerebellar lobule segmentation using ultra-high resolution multimodal MRI.

NeuroImage·2025

Area of Science:

  • Neuroscience
  • Pharmacology
  • Reproductive Biology

Background:

  • Labor pain is a significant clinical issue with poorly understood neurophysiology.
  • The parturient rat is proposed as a model to investigate labor pain pharmacology.

Purpose of the Study:

  • To evaluate the parturient rat as a model for studying labor pain.
  • To investigate the neurophysiological basis of labor pain behaviors.

Main Methods:

  • Birth timing in rats was controlled using RU 486.
  • Behavioral events and spinal neuronal activity (c-Fos protein) during labor were analyzed.
  • The effects of epidural morphine on labor behaviors and neuronal activity were assessed.

Main Results:

Related Experiment Videos

  • Labor in rats involved characteristic stretches linked to uterine contractions.
  • Epidural morphine significantly reduced labor-related stretches and spinal neuronal activation.
  • Morphine did not alter the duration of labor.

    • Conclusions:

    • Stretches during rat labor represent a behavioral response to nociception from uterine contractions.
    • The parturient rat serves as a relevant model for investigating parturition-related nociceptive mechanisms relevant to humans.