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Outbreak of Kingella kingae skeletal system infections in children in daycare

Pablo Yagupsky1, Yifat Erlich, Slonim Ariela

  • 1Clinical Microbiology Laboratory, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel. yagupsky@bgumail.bgu.ac.il

The Pediatric Infectious Disease Journal
|May 30, 2006
PubMed

Insights

An outbreak of Kingella kingae osteomyelitis occurred in an Israeli daycare center. Surveillance and prophylaxis helped control the spread of this invasive pediatric infection.

Area of Science:

  • Pediatric Infectious Diseases
  • Microbiology
  • Epidemiology

Background:

  • Kingella kingae is an emerging cause of invasive pediatric infections, particularly osteomyelitis.
  • Daycare centers can facilitate the rapid transmission of infectious agents among young children.

Purpose of the Study:

  • To investigate an outbreak of Kingella kingae osteomyelitis in a daycare setting.
  • To understand the transmission dynamics and implement control measures for K. kingae infections.

Main Methods:

  • Conducted surveillance pharyngeal cultures in daycare attendees.
  • Utilized molecular typing (PFGE, RAPD, rRNA sequencing) to characterize K. kingae isolates.
  • Administered community-wide antibiotic prophylaxis (amoxicillin-rifampin).

Main Results:

  • Identified K. kingae carriage in daycare attendees, with identical isolates from the index case and other children in the same facility.
  • Molecular typing confirmed the outbreak strain's origin within the index daycare center.
  • Prophylactic antibiotics achieved partial eradication of K. kingae.

Conclusions:

  • K. kingae outbreaks in pediatric populations, like daycare centers, can arise from rapid dissemination.
  • Increased vigilance for clusters of K. kingae infections in childcare settings is crucial.
Abstract

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