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Related Experiment Videos

Mitochondrial DNA sequence polymorphism, VO2max, and response to endurance training.

F T Dionne1, L Turcotte, M C Thibault

  • 1Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Québec, Canada.

Medicine and Science in Sports and Exercise
|February 1, 1991
PubMed
Summary

Mitochondrial DNA variations influence maximal oxygen uptake (VO2max) and endurance training response. Specific gene variants are linked to higher or lower initial VO2max and altered training adaptations.

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Area of Science:

  • Exercise Physiology
  • Human Genetics
  • Mitochondrial Biology

Background:

  • Individual differences in maximal oxygen uptake (VO2max) and training response are significant.
  • The role of mitochondrial DNA (mtDNA) in these variations is not fully understood.

Purpose of the Study:

  • To investigate the association between mtDNA sequence variation and VO2max in sedentary young males.
  • To determine if mtDNA variants affect the individual response to endurance training.

Main Methods:

  • Mitochondrial DNA was analyzed using restriction fragment length polymorphism (RFLP) in 46 sedentary young adult males.
  • VO2max was measured via progressive ergocycle testing before and after endurance training.
  • mtDNA variants were correlated with baseline VO2max and training-induced changes.

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Main Results:

  • Multiple mtDNA variants were detected, with some individuals showing significant variation and others none.
  • Specific mtDNA morphs in NADH dehydrogenase genes and tRNA for threonine were associated with higher or lower baseline VO2max.
  • Carriers of an mtDNA variant in NADH dehydrogenase subunit 5 showed a blunted VO2max response to endurance training.

Conclusions:

  • Mitochondrial DNA sequence variation may contribute to individual differences in VO2max.
  • Specific mtDNA variants appear to influence the physiological adaptations to endurance exercise training.