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Updated: Jul 9, 2026

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
Published on: November 8, 2016
The autoimmune regulator (Aire) controls iNKT cell development and maturation
Qing-Sheng Mi1, Zhong-Bin Deng, Sunil K Joshi
1Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912, USA. qmi@mail.mcg.edu
Abstract:
The mechanism underlying the autoimmune polyglandular syndrome type-1 (APS1) has been attributed to defective T-cell negative selection resulting from reduced expression and presentation of autoantigens in thymic medullary epithelial cells (MECs). It has also been postulated that Aire is involved in development of regulatory T cells, although supporting evidence is lacking. Here we show that expression of Aire in MECs is required for development of iNKT cells, suggesting a role for iNKT cells in APS1.
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