Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute rejection after heart transplantation.

Juan F Delgado1, Violeta Sánchez, Carlos S de la Calzada

  • 1Heart Failure and Transplant Unit, Cardiology Department, Doce de Octubre Universitary Hospital, Avenida de Córdoba sn, 28041 Madrid, Spain. jdelgado.hdoc@salud.madrid.org

Expert Opinion on Pharmacotherapy
|May 31, 2006
PubMed
Summary

Acute rejection (AR) after heart transplantation is a significant cause of early mortality. This review examines recent studies on AR

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Phenotypes in Heart Transplantation: Implications for Prognosis and Personalized Follow-up.

Transplantation·2026
Same author

Balancing Risk and Hope: Insights Into Pregnancy Outcomes in Pulmonary Arterial Hypertension.

Pulmonary circulation·2026
Same author

Monitoring systemic immune responses to checkpoint inhibition in breast cancer reveals host responses and mechanisms of resistance.

Journal for immunotherapy of cancer·2025
Same author

The Impact of JAK1 Pathogenic Variants and MHC-I Expression on Response to Immune Checkpoint Inhibition in Endometrial Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2025
Same author

Clonal Hematopoiesis of Indeterminate Potential Influences Breast Cancer Outcomes in a Genotype-Specific Manner.

Clinical cancer research : an official journal of the American Association for Cancer Research·2025
Same author

Plasma metabolites in patients of the REDINSCOR III registry hospitalised for de novo heart failure with preserved ejection fraction: Prognostic implications of linoleamide and 2-trans,4-cisdecadienoylcarnitine levels.

Clinical and translational medicine·2025

Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Immunology

Background:

  • Acute rejection (AR) remains a primary cause of morbidity and mortality within the first year post-heart transplantation.
  • Current immunosuppressive strategies have reduced AR incidence but clinical management remains complex.
  • Endomyocardial biopsy is the gold standard for AR detection, with ongoing refinements in cardiac biopsy grading systems.

Purpose of the Study:

  • To review recent literature on the clinical impact of acute rejection in heart transplantation.
  • To analyze current combination regimens for chronic maintenance immunosuppression.
  • To discuss specific therapeutic options for treating acute rejection.

Main Methods:

  • Literature review of recently published studies.

Related Experiment Videos

  • Focus on clinical impact, immunosuppressive combinations, and treatment strategies for AR.
  • Analysis of data related to AR in heart transplant recipients.

    • Main Results:

    • Acute rejection, though less common, still poses significant risks in the early post-transplant period.
    • Diverse immunosuppressive drug combinations exist, leading to clinical uncertainty.
    • Established and emerging therapeutic strategies for AR are being evaluated.

    Conclusions:

    • Despite advances, acute rejection remains a critical concern in heart transplantation.
    • Understanding optimal immunosuppression and AR treatment is vital for improving patient outcomes.
    • Further research is needed to refine AR diagnosis and management protocols.