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EPA Method 1615. Measurement of Enterovirus and Norovirus Occurrence in Water by Culture and RT-qPCR. I. Collection of Virus Samples
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Published on: March 28, 2015

Critical management in patients with severe enterovirus 71 infection

Jieh-Neng Wang1, Chih-Ta Yao, Cheng-Nan Yeh

  • 1Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Pediatrics International : Official Journal of the Japan Pediatric Society
|May 31, 2006
PubMed

Insights

Early cardiopulmonary support and milrinone improve outcomes in severe enterovirus 71 (EV71) infection. This critical care strategy enhances survival rates in pediatric patients with EV71.

Area of Science:

  • Pediatric critical care medicine
  • Infectious diseases
  • Virology

Background:

  • Severe enterovirus 71 (EV71) infection poses a significant threat to children.
  • Effective critical care strategies are crucial for improving patient outcomes.

Purpose of the Study:

  • To analyze clinical details of severe EV71 infection in children.
  • To synthesize critical care experience for managing severe EV71 infection.

Main Methods:

  • Retrospective analysis of pediatric patients with severe EV71 infection.
  • Comparison of a control group (March 1998-April 2000) with a study group receiving protocol therapy (May 2000-March 2003).
  • Detailed collection of clinical and pharmacological data for comparison.

Main Results:

  • No significant difference in clinical presentations or laboratory findings between groups.
  • Lower intravenous fluid administration in the study group (4.9 vs 9.2 mL/kg per h).
  • Higher survival rates in the study group (100% acute, 87% long-term) compared to the control group (43% acute, 29% long-term).
  • Specific pharmacological interventions differed: more dopamine and less epinephrine in the study group; milrinone used in the study group.

Conclusions:

  • Early cardiopulmonary support is vital to prevent cardiopulmonary failure and improve outcomes in severe EV71 infection.
  • Milrinone appears to be an effective inotropic agent for these patients.
  • Echocardiography, central lines, and arterial lines can guide management, potentially replacing direct intracardiac monitoring.
Abstract

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