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Related Experiment Videos

Spot urinary creatinine excretion in pervasive developmental disorders.

Paul Whiteley1, Rosemary Waring, Lee Williams

  • 1Autism Research Unit, School of Health, Natural & Social Sciences, University of Sunderland, Sunderland, UK. paul.whiteley@sunderland.ac.uk

Pediatrics International : Official Journal of the Japan Pediatric Society
|May 31, 2006
PubMed
Summary

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Children with Pervasive Developmental Disorders (PDD) showed significantly lower urinary creatinine levels compared to controls. This finding suggests potential differences in metabolism or renal function in PDD, warranting further investigation into biomarkers.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Neurodevelopmental Disorders

Background:

  • Urinary creatinine measurement is standard for normalizing urine concentration in research.
  • Creatinine reflects muscle energy metabolism and is a key metabolite.
  • Its role in Pervasive Developmental Disorders (PDD) requires further study.

Purpose of the Study:

  • To investigate urinary creatinine levels in children diagnosed with PDD.
  • To compare creatinine excretion between PDD and typically developing children.
  • To assess the utility of spot urine creatinine in PDD research.

Main Methods:

  • Analyzed spot urine samples from 24 children with PDD and 50 controls.
  • Confirmed PDD diagnosis using the Autism Diagnostic Interview-Revised.

Related Experiment Videos

  • Measured creatinine using an improved Jaffe's reaction method, controlling for pH and BMI.

    • Main Results:

    • A statistically significant decrease in urinary creatinine concentration was observed in the PDD group compared to controls (P=0.001).
    • This reduction was identified after controlling for potential confounding factors like sample pH and body mass index.

    Conclusions:

    • Preliminary findings indicate lower urinary creatinine excretion in children with PDD.
    • Further research on protein catabolism and renal function in autism is needed.
    • The study highlights potential limitations of single urine creatinine measurements in PDD research and suggests exploring alternative standards.